RNA Details
Disease Name
endomyocardial fibrosis
Tissue
heart
RNA Symbol
Irf1
RNA ID
RNA Type
mRNA
Alteration Pattern
sumoylation
Species
mus musculus
Detection Methods
PCR; immunofluorescence etc.
Target
NA
Pathway
JAK-STAT SIGNALING PATHWAY
PubMed ID
Title
5-Azacytidine modulates interferon regulatory factor 1 in macrophages to exert a cardioprotective effect.Epigenetic Therapy for the Treatment of Hypertension-Induced Cardiac Hypertrophy and Fibrosis
Year
2015
Function
5-azacytidine (5AZ) had a protective effect after mi by potentiation of IRF1 sumoylation and is suggested as a novel therapeutic intervention for cardiac repair.